VU0405645 | M1 Receptor PAM | Probechem Biochemicals

Chemical Structure : VU0405645

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VU0405645 (VU 0405645)

货号: PC-49070Not For Human Use, Lab Use Only.

VU0405645 is a potent, biased M1 receptor-positive allosteric modulator, potentiates Ca2+ mobilization in CHO cells stably expressing the M1 receptor with EC50 of 340 nM.

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生物&药学活性

VU0405645 is a potent, biased M1 receptor-positive allosteric modulator, potentiates Ca2+ mobilization in CHO cells stably expressing the M1 receptor with EC50 of 340 nM.
VU0405645 does not potentiate the CCh-dependent activation of PLD in in vitro assay.
VU0405645 potentiates agonist-induced increases in spontaneous excitatory postsynaptic currents (sEPSCs).
VU0405645 potentiates an increase in SPN excitability in response to a submaximal concentration of CCh.

物理化学性质&存储条件

分子量	511.504
分子式	C24H19F2N5O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-[4,6-difluoro-1-[3-(1H-pyrazol-4-yl)benzyl]indol-3-yl]sulfonyl-N-(5-methylisoxazol-3-yl)acetamide

参考文献

1. Sean P Moran, et al. Sci Signal. 2019 Dec 3;12(610):eaax2057.

VU0405645 (VU 0405645)

生物&药学活性

物理化学性质&存储条件

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VU0405645 (VU 0405645)

生物&药学活性

物理化学性质&存储条件

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