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首页-小分子抑制剂&激动剂-GPCR-mAChR-MK-7622
MK-7622

Chemical Structure : MK-7622

CAS No.: 1227923-29-6

MK-7622 (MK7622)

货号: PC-22975Not For Human Use, Lab Use Only.

MK-7622 is a potent, selective and CNS penetrant M1 muscarinic receptor positive allosteric modulator (PAM).

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10 mg ¥880 In stock
25 mg ¥1380 In stock
50 mg ¥2280 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

MK-7622 is a potent, selective and CNS penetrant M1 muscarinic receptor positive allosteric modulator (PAM).
MK-7622 attenuated the cognitive-impairing effects of the muscarinic receptor antagonist scopolamine and altered quantitative electroencephalography (qEEG) in both rhesus macaque and human.

物理化学性质&存储条件

分子量 399.49
分子式 C25H25N3O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

3-[(1S,2S)-2-Hydroxycyclohexyl]-6-[(6-methyl-3-pyridinyl)methyl]benzo[h]quinazolin-4(3H)-one

参考文献

1. Uslaner JM, et al. J Pharmacol Exp Ther. 2018 Jun;365(3):556-566.

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