| Cat. No. |
Product Name |
Information |
| PC-49446 |
TNF inhibitor TIM1c
TNF inhibitor
|
TNF inhibitor TIM1c is an orally active small molecule inhibitor of TNF, potently inhibit TNF-induced cell death and cytokine secretion, prevents homotrimerization of TNF by directly binding to the TNF monomer with SPR KD of 1.55 and 0.68 uM for rmTNF and rhTNF, respectively. |
| PC-49445 |
UCB-5307
TNF inhibitor
|
UCB-5307 is a small molecule compound inhibiting TNFR1 signalling and downstream function in vitro, bind directly to TNF with slow binding kinetics (KD= 6 nM). |
| PC-35772 |
SIG-1191
|
SIG-1191 (SIG1191) is a soprenylcysteine (IPC) small molecule with anti-inflammatory activity, inhibits UVB-induced inflammation blocking pro-inflammatory cytokine interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-α) production. |
| PC-62163 |
JNJ525
TNFα inhibitor
|
JNJ525 is a small molecule inhibitor of TNFα that prevents the formation of TNFα complexes with TNFR1 and TNFR2 with IC50 of 1.2 uM and 1.1 uM in the TR-FRET assay, respectively. |
| PC-61313 |
SPD-304
TNFα inhibitor
|
SPD-304 is an inhibitor of tumor necrosis factor α (TNFα) that prevents binding to the TNF Receptor 1 (TNFR1) with IC50 of 22 uM. |
| PC-70230 |
IW-927
TNFα inhibitor
|
IW-927 is a potent TNFα/TNFRc1 interaction antagonist with IC50 of 50 nM, with no affinity for the related cytokine receptors TNFRc2 or CD40, and no cytotoxicity (>100 uM). |
| PC-42764 |
Pomalidomide
|
Pomalidomide (CC4047) is a potent IKZF1 degrader with DC50 of 6 nM and Dmax=86%, has no effect on IKZF2 protein levels up to 50 μM. |
| PC-61792 |
UTL-5g
|
UTL-5g (GBL-5g) is a novel potential chemoprotective agent, TNF-α inhibitor that reduces cisplatin-induced side effects including nephrotoxicity, hepatotoxicity and hematotoxicity. |
| PC-61278 |
LMP-420
|
A small-molecule, orally active inhibitor of TNF-α that reduces replication of HIV-1 (IC50=300 nM) and Mycobacterium tuberculosis in human cells. |
| PC-60273 |
Mitochonic Acid 35
|
A dual inhibitor of TNF-α and TGF-β1 by inhibiting IκB kinase phosphorylation and Smad3 phosphorylation. |
| PC-42239 |
TNFα-IN-C87
|
A novel and highly specific small-molecule TNFα inhibitor that directly binds to TNFα, potently inhibits TNFα-induced cell death (IC50=8.73 uM) and effectively blocks TNFα-triggered signaling activities. |
