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首页-小分子抑制剂&激动剂-Apoptosis-TNF-alpha-TNFα-IN-C87
TNFα-IN-C87

Chemical Structure : TNFα-IN-C87

CAS No.: 332420-90-3

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TNFα-IN-C87 (C87;C-87;C 87)

货号: PC-42239Not For Human Use, Lab Use Only.

A novel and highly specific small-molecule TNFα inhibitor that directly binds to TNFα, potently inhibits TNFα-induced cell death (IC50=8.73 uM) and effectively blocks TNFα-triggered signaling activities.

规格 价格 库存 数量
10 mg ￥1200 In stock
25 mg ￥2480 In stock
50 mg ￥4464.0 In stock
100 mg ￥7984.0 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

A novel and highly specific small-molecule TNFα inhibitor that directly binds to TNFα, potently inhibits TNFα-induced cell death (IC50=8.73 uM) and effectively blocks TNFα-triggered signaling activities; effectively attenuates TNFα-induced inflammation in a murine acute hepatitis model.

物理化学性质&存储条件

分子量 502.9323
分子式 C24H15ClN6O3S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: 9.33 mg/mL
Chemical Name/SMILES

1H-Pyrazole-4,5-dione, 3-phenyl-1-(4-phenyl-2-thiazolyl)-, 4-[2-(4-chloro-3-nitrophenyl)hydrazone]

参考文献

1. Ma L, et al. J Biol Chem. 2014 May 2;289(18):12457-66.

2. Chen S, et al. J Chem Inf Model. 2017 May 22;57(5):1101-1111.

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