Y2641 | RANKL/TNF-α inhibitor | Probechem Biochemicals

Chemical Structure : Y2641

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Y2641 (Y-2641)

货号: PC-25332Not For Human Use, Lab Use Only.

Y2641 is a potent, dual RANKL and TNF-α inhibitor with binding affinity (KD) of 3.984 uM) and 18.59 uM respectively, exhibits potent RANKL-induced osteoclastogenic inhibition with IC50 of 109.1 nM.

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生物&药学活性

Y2641 is a potent, dual RANKL and TNF-α inhibitor with binding affinity (KD) of 3.984 uM) and 18.59 uM respectively, exhibits potent RANKL-induced osteoclastogenic inhibition with IC50 of 109.1 nM.
Y2641 exhibits significant TNF-α/LPS-induced inflammation inhibitory activity in vitro via inhibiting TNF-α related NF-κΒ signaling pathway.
Y2641 simultaneously has cartilage catabolic inhibition and cartilage anabolic promotion in primary chondrocyte.
Y2641 significantly reduces the subchondral bone resorption and cartilage destruction in anterior cruciate ligament transection (ACLT)-induced OA rats.

物理化学性质&存储条件

分子量	436.56
分子式	C28H28N4O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-N-(2,6-dimethylphenyl)-1-phenyl-2',3',4',9'-tetrahydrospiro[azetidine-3,1'-pyrido[3,4-b]indole]-3'-carboxamide

参考文献

1. Shao Z, et al. J Med Chem. 2025 May 22;68(10):10216-10237.

Y2641 (Y-2641)

生物&药学活性

物理化学性质&存储条件

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Y2641 (Y-2641)

生物&药学活性

物理化学性质&存储条件

参考文献

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