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首页-小分子抑制剂&激动剂-Apoptosis-TNF-alpha-TNF inhibitor TIM1c
TNF inhibitor TIM1c

Chemical Structure : TNF inhibitor TIM1c

CAS No.: 1171311-99-1

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TNF inhibitor TIM1c (TIM1c)

货号: PC-49446Not For Human Use, Lab Use Only.

TNF inhibitor TIM1c is an orally active small molecule inhibitor of TNF, potently inhibit TNF-induced cell death and cytokine secretion, prevents homotrimerization of TNF by directly binding to the TNF monomer with SPR KD of 1.55 and 0.68 uM for rmTNF and rhTNF, respectively.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    TNF inhibitor TIM1c is an orally active small molecule inhibitor of TNF, potently inhibit TNF-induced cell death and cytokine secretion, prevents homotrimerization of TNF by directly binding to the TNF monomer with SPR KD of 1.55 and 0.68 uM for rmTNF and rhTNF, respectively.
    TNF inhibitor TIM1c stably occupies the TNF homodimer through nonpolar interactions.
    TNF inhibitor TIM1c displays negligible cytotoxicity and great inhibition of TNF-driven induction of IL-8 and IL-6 in human dermal fibroblasts.
    TNF inhibitor TIM1c (20 mg/kg) showed oral bioactivity in a mouse model of collagen-induced polyarthritis (CIA) and suppressed arthritis symptoms, reduces IL-1β and IL-6 immunopositive cells.
    TNF inhibitor TIM1c is a specific and potent disruptor of TNF homotrimerization.

    物理化学性质&存储条件

    分子量 436.534
    分子式 C22H24N6O2S
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(2,5-dimethyl-3-(2-(propylamino)thiazol-4-yl)-1H-pyrrol-1-yl)-3-methyl-4-oxo-3,4-dihydrophthalazine-1-carboxamide

    参考文献

    1. Javaid N, et al. Sci Signal. 2022 Nov 8;15(759):eabi8713.

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