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首页-小分子抑制剂&激动剂-Apoptosis-TNF-alpha-SIG-1191
SIG-1191

Chemical Structure : SIG-1191

CAS No.: 1227280-36-5

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SIG-1191 (SIG1191, SIG 1191)

货号: PC-35772Not For Human Use, Lab Use Only.

SIG-1191 (SIG1191) is a soprenylcysteine (IPC) small molecule with anti-inflammatory activity, inhibits UVB-induced inflammation blocking pro-inflammatory cytokine interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-α) production.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    SIG-1191 (SIG1191) is a soprenylcysteine (IPC) small molecule with anti-inflammatory activity, inhibits UVB-induced inflammation blocking pro-inflammatory cytokine interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-α) production.
    SIG-1191 increases AQP3 expression in cultured normal human epidermal keratinocytes, dose dependently increased AQP3 protein levels.

    物理化学性质&存储条件

    分子量 495.679
    分子式 C25H41N3O5S
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(acetylglutaminyl)-S-((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl)-L-cysteine

    参考文献

    1. Fernández JR, et al. Arch Dermatol Res. 2017 Mar;309(2):103-110.

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