LMP-420 |CAS:473870-63-2 Probechem Biochemicals

Chemical Structure : LMP-420

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LMP-420 (LMP 420;LMP420)

货号: PC-61278Not For Human Use, Lab Use Only.

A small-molecule, orally active inhibitor of TNF-α that reduces replication of HIV-1 (IC50=300 nM) and Mycobacterium tuberculosis in human cells.

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1 g		Get quote

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生物&药学活性

A small-molecule, orally active inhibitor of TNF-α that reduces replication of HIV-1 (IC50=300 nM) and Mycobacterium tuberculosis in human cells; also shows potent cytotoxic effects for CLL cells (ED50=245 nM, 72h) and minimal toxicity for normal hematopoietic cells; decreases colonic TNF levels in IL-10-deficient mice with chronic colitis.

物理化学性质&存储条件

分子量	283.523
分子式	C10H15BClN5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(5-(2-amino-6-chloro-9H-purin-9-yl)pentyl)boronic acid

参考文献

1. Haraguchi S, et al. AIDS Res Ther. 2006 Mar 31;3:8.

2. Hale LP, et al. J Inflamm (Lond). 2008 Mar 10;5:4.

3. Mowery YM, et al. Leukemia. 2010 Sep;24(9):1580-7.

4. Angaswamy N, et al. Cell Transplant. 2012;21(6):1285-96.

LMP-420 (LMP 420;LMP420)

生物&药学活性

物理化学性质&存储条件

参考文献

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LMP-420 (LMP 420;LMP420)

生物&药学活性

物理化学性质&存储条件

参考文献

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