IW-927 |CAS:389142-48-7 Probechem Biochemicals

Chemical Structure : IW-927

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IW-927 (IW927;IW 927)

货号: PC-70230Not For Human Use, Lab Use Only.

IW-927 is a potent TNFα/TNFRc1 interaction antagonist with IC50 of 50 nM, with no affinity for the related cytokine receptors TNFRc2 or CD40, and no cytotoxicity (>100 uM).

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生物&药学活性

IW-927 is a potent TNFα/TNFRc1 interaction antagonist with IC50 of 50 nM, with no affinity for the related cytokine receptors TNFRc2 or CD40, and no cytotoxicity (>100 uM).
IW-927 also blocks TNF-stimulated phosphorylation of Ikappa-B in Ramos cells (IC50=600 nM)

物理化学性质&存储条件

分子量	441.564
分子式	C22H23N3O3S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(3-methoxyphenyl)-6-(3-morpholinopropyl)-5-thioxo-5,6-dihydro-7H-thieno[2',3':4,5]pyrrolo[1,2-c]imidazol-7-one

参考文献

1. Carter PH, et al. Proc Natl Acad Sci U S A. 2001 Oct 9;98(21):11879-84.

IW-927 (IW927;IW 927)

生物&药学活性

物理化学性质&存储条件

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IW-927 (IW927;IW 927)

生物&药学活性

物理化学性质&存储条件

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