| Cat. No. |
Product Name |
Information |
| PC-72059 |
ER-851
Axl inhibitor
|
ER-851 (ER-001259851-000) is a potent, selective, orally active Axl inhibitor with IC50 of 5.2 nM in cell free assays, displays >35-fold selectivity against Mer (IC50=190 nM). |
| PC-38043 |
DS-1205b
Axl inhibitor
|
DS-1205b (DS1205b) is a potent, highly selective inhibitor of AXL kinase with IC50 of 1.3 nM. |
| PC-35790 |
UNC4203
Mer inhibitor
|
UNC4203 (UNC-4203) is a potent, highly selective MerTK with IC50 of 2.4 nM, displays >30- and 4 -foldfold selectivity over Alx (IC50=80 nM) and Tyro3 (IC50=9.1 nM). |
| PC-35348 |
R916562
Axl/VEGFR2 inhibitor
|
R916562 (R562) is a potent, dual Axl/VEGFR2 inhibitor with celluar IC50 of 136 nM for Axl. |
| PC-43299 |
S49076
MET/FGFR inhibitor
|
S49076 is a potent, ATP-competitive tyrosine kinase inhibitor of MET, AXL/MER, and FGFR1/2/3 with IC50 of <20 nM, also potently inhibits the kinase activity of mutated isoforms of MET (D1246N, Y1248D, Y1248H) and FGFR1/2. |
| PC-43298 |
SGI-7079
Axl inhibitor
|
SGI-7079 is a potent, selective Axl inhibitor with Ki of 5.7 nM, inhibits Gas6 ligand-induced tyrosine phosphorylation of human AXL expressed in HEK293T cells with EC50 of 100 nM. |
| PC-43297 |
TP-0903
Axl inhibitor
|
TP-0903 (Dubermatinib, TP0903) is a potent, selective, orally bioavailable Axl inhibitor with IC50 of 27 nM inhibits cell viability of pncreactic cancer cells (PSN1) with IC50 of 6 nM. |
| PC-63226 |
UNC569
Mer inhibitor
|
UNC569 is a potent, small-molecule Mer kinase inhibitor with IC50 of 2.9 nM, 37 nM and 48 nM for Mer, Axl and Tyro3, respectively. |
| PC-63225 |
UNC1666
Mer/FLT3 inhibitor
|
UNC1666 is a potent, specific dual Mer and Flt3 tyrosine kinase inhibitor with IC50 of 0.55 and 0.69 nM. |
| PC-43061 |
LDC1267
TAM receptor inhibitor
|
LDC1267 is a potent, highly selective TAM receptor (Tyro3, Axl and Mer) kinase inhibitor with IC50 of <5 nM/8 nM/29 nM for Tyro3, Axl and Mer, respectively. |
| PC-42994 |
UNC2025 hydrochloride
Mer/FLT3 inhibitor
|
UNC2025 is a potent, orally bioavailable Mer/FLT3 dual inhibitor with IC50 of 0.74/0.8 nM, 700-fold less active against Met compared to Mer. |
| PC-42993 |
UNC2025
Mer/FLT3 inhibitor
|
UNC2025 is a potent, orally bioavailable Mer/FLT3 dual inhibitor with IC50 of 0.74/0.8 nM, 700-fold less active against Met compared to Mer. |
