ER-851 | Axl inhibitor | Probechem Biochemicals

Chemical Structure : ER-851

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ER-851 (ER851, ER-001259851-000)

货号: PC-72059Not For Human Use, Lab Use Only.

ER-851 (ER-001259851-000) is a potent, selective, orally active Axl inhibitor with IC50 of 5.2 nM in cell free assays, displays >35-fold selectivity against Mer (IC50=190 nM).

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生物&药学活性

ER-851 (ER-001259851-000) is a potent, selective, orally active Axl inhibitor with IC50 of 5.2 nM in cell free assays, displays >35-fold selectivity against Mer (IC50=190 nM).
ER-001259851-000 shows a promising pharmacokinetic profile in mice.

物理化学性质&存储条件

分子量	668.774
分子式	C36H41FN8O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 Month
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Solubility	10 mM in DMSO
Chemical Name/SMILES	1-cyclopentyl-N-(3-fluoro-4-((7-((1-methylpiperidin-4-yl)methyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl)oxy)phenyl)-3-(5-methylpyridin-2-yl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide

参考文献

1. Satoshi Inoue, et al. Bioorg Med Chem Lett. 2021 Sep 15;48:128247.

ER-851 (ER851, ER-001259851-000)

生物&药学活性

物理化学性质&存储条件

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ER-851 (ER851, ER-001259851-000)

生物&药学活性

物理化学性质&存储条件

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