| Cat. No. |
Product Name |
Information |
| PC-62809 |
Axl-IN-21
|
Axl-IN-21 is a selective and potent inhibitor of wild-type Axl with IC50 of 2.2 nM. |
| PC-61780 |
TAM-IN-1
Mer/Axl inhibitor
|
TAM-IN-1 is a highly potent, macrocyclic inhibitor of Mer and Axl with Ki of <50 pM and 130 pM, respectively. |
| PC-61679 |
UNC-1062
Mer inhibitor
|
UNC-1062 is a potent and selective Mer kinase inhibitor with IC50 of 1.1 nM, Ki of 0.33 nM. |
| PC-61325 |
N-butylidenephthalide
|
N-butylidenephthalide (NSC 325307) is a natural compound derived from Angelica sinensis that inhibits malignant brain tumor growth in vitro and in vivo. |
| PC-60247 |
RU-302
TAM receptor inhibitor
|
RU-302 is a small molecule pan-TAM inhibitor that targets the TAM Ig1-Gas6 interface, blocks Gas6-dependent TAM activation. |
| PC-60246 |
RU-301
TAM receptor inhibitor
|
RU-301 (RU301) is a small molecule pan-TAM (Tyro3-Axl-Mer)) inhibitor that targets the TAM Ig1-Gas6 interface, blocks Gas6-dependent TAM activation. |
| PC-45668 |
Glesatinib hydrochloride
AXL/c-Met inhibitor
|
Glesatinib (MGCD265) hydrochloride is a tyrosine kinase inhibitor that potently and selectively inhibits Met and Axl kinase. |
| PC-42292 |
CEP-40783
AXL/c-Met inhibitor
|
CEP-40783 (CEP40783, RXDX-106) is a potent and selective AXL/c-Met inhibitor with IC50 of 7 nM/12 nM. |
| PC-23043 |
UNC2541
Mer inhibitor
|
UNC2541 is a potent, specific Mer tyrosine kinase (MerTK) inhibitor with IC50 of 4.4 nM, >25-fold selective over Tyro3, Axl, and FLT3, shows EC50 of 550 nM in pMerTK ELISA assays. |
| PC-23042 |
UNC8969
Mer/Axl inhibitor
|
UNC8969 is a potent, selective, macrocyclic dual MerTK/Axl inhibitor with IC50 of 1.1/5.3 nM respectively, >12-fold selectivity over TYRO3 and FLT3. |
| PC-23041 |
A-910
Mer/Axl inhibitor
|
A-910 is a highly potent and selective, orally active dual MerTK/Axl inhibitor with IC50 of 0.2/0.9 nM respectively, >200-fold selective over Tyro3. |
| PC-20332 |
INCB081776
AXL/MER inhibitor
|
INCB081776 is a potent and selective dual inhibitor of AXL and MERTK with IC50 of 16 and 14 nM respectively, 30-fold selectivity over TYRO3. |
