UNC1666 |CAS:1429882-12-1 Probechem Biochemicals

Chemical Structure : UNC1666

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UNC1666 (UNC 1666)

货号: PC-63225Not For Human Use, Lab Use Only.

UNC1666 is a potent, specific dual Mer and Flt3 tyrosine kinase inhibitor with IC50 of 0.55 and 0.69 nM.

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生物&药学活性

UNC1666 is a potent, specific dual Mer and Flt3 tyrosine kinase inhibitor with IC50 of 0.55 and 0.69 nM.
UNC1666 only potently inhibits TrkA (IC50=0.57 uM) in a comprehensive protein kinase profiling panel, inhibits Tyro-3 and Axl with IC50 of 29 nM and 37 nM (>30-fold selectivity).
UNC1666 reduced Mer and Flt3 phosphorylation in Flt3-ITD cell lines, inhibits Erk1/2, Akt and Stat6 phosphorylation in Mer expressing cell lines.
UNC1666 reduces Mer and Flt3-mediated anti-apoptotic and pro-survival signaling, induces apoptosis in AML cells.

物理化学性质&存储条件

分子量	513.657
分子式	C26H35N5O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(1r,4r)-4-(2-(butylamino)-5-(4-(morpholinosulfonyl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclohexan-1-ol

参考文献

1. Lee-Sherick AB, et al. Oncotarget. 2015 Mar 30;6(9):6722-36.

UNC1666 (UNC 1666)

生物&药学活性

物理化学性质&存储条件

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UNC1666 (UNC 1666)

生物&药学活性

物理化学性质&存储条件

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