Axl-IN-21 |CAS:2086274-31-7 Probechem Biochemicals

Chemical Structure : Axl-IN-21

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Axl-IN-21

货号: PC-62809Not For Human Use, Lab Use Only.

Axl-IN-21 is a selective and potent inhibitor of wild-type Axl with IC50 of 2.2 nM.

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生物&药学活性

Axl-IN-21 is a selective and potent inhibitor of wild-type Axl with IC50 of 2.2 nM; shows high selectivity in a 56 kinase panel, no CYP inhibition across the CYP isoforms; shows good permeability in PAMPA assay, and demonstrates good oral exposure in rat PK studies (F=38%, CL=53 (mg/kg/min)); a useful molecule for further in vivo target validation studies to support the role of Axl in cancer.

物理化学性质&存储条件

分子量	518.607
分子式	C22H26N6O5S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-N-(2-(4-(4-(methylsulfonyl)morpholin-2-yl)thiazol-2-yl)-4-morpholinophenyl)-1H-imidazole-2-carboxamide

参考文献

1. Keung W, et al. Bioorg Med Chem Lett. 2017 Feb 15;27(4):1099-1104.

Axl-IN-21

生物&药学活性

物理化学性质&存储条件

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Axl-IN-21

生物&药学活性

物理化学性质&存储条件

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