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首页-小分子抑制剂&激动剂-Tyrosine Kinase-TAM Receptor (Tyro3-Axl-Mer)-RU-302
RU-302

Chemical Structure : RU-302

CAS No.: 1182129-77-6

RU-302 (RU 302;RU302)

货号: PC-60247Not For Human Use, Lab Use Only.

RU-302 is a small molecule pan-TAM inhibitor that targets the TAM Ig1-Gas6 interface, blocks Gas6-dependent TAM activation.

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5 mg ¥1280 In stock
10 mg ¥1980 In stock
25 mg ¥3280 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

RU-302 is a small molecule pan-TAM inhibitor that targets the TAM Ig1-Gas6 interface, blocks Gas6-dependent TAM activation.
RU-302 effectively blocks Gas6-inducible Axl receptor activation with low micromolar IC50s.
RU-302 inhibits Gas6-inducible motility in Axl-expressing cell lines, and suppress H1299 lung cancer tumor growth in a mouse xenograft NOD-SCIDγ model.

物理化学性质&存储条件

分子量 475.53
分子式 C24H24F3N3O2S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(2-(((3,5-dimethylisoxazol-4-yl)methyl)thio)phenyl)(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)methanone

参考文献

1. Kimani SG, et al. Sci Rep. 2017 Mar 8;7:43908.

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