UNC-1062 |CAS:1350549-36-8 Probechem Biochemicals

Chemical Structure : UNC-1062

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UNC-1062 (UNC1062)

货号: PC-61679Not For Human Use, Lab Use Only.

UNC-1062 is a potent and selective Mer kinase inhibitor with IC50 of 1.1 nM, Ki of 0.33 nM.

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生物&药学活性

UNC-1062 is a potent and selective Mer kinase inhibitor with IC50 of 1.1 nM, Ki of 0.33 nM.
UNC-1062 shows improved selectivity and activity against Mer relative to other TAM family RTKs (78-fold selectivity over Axl and 36-fold over Tyro3).
UNC-1062 inhibits Mer auto-phosphorylation in human pre-B leukemia 697 cells with IC50 of 6.4 nM, also inhibits colony formation in soft agar in tumor cells.

物理化学性质&存储条件

分子量	514.64
分子式	C25H34N6O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	4-[6-(Butylamino)-3-[4-(4-morpholinylsulfonyl)phenyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-cyclohexanol

参考文献

1. Schlegel J, et al. J Clin Invest. 2013 May;123(5):2257-67.

2. Liu J, et al. Eur J Med Chem. 2013 Jul;65:83-93.

3. von Mässenhausen A, et al. Oncotarget. 2016 May 31;7(22):32678-94.

UNC-1062 (UNC1062)

生物&药学活性

物理化学性质&存储条件

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UNC-1062 (UNC1062)

生物&药学活性

物理化学性质&存储条件

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