LDC1267 |CAS:1361030-48-9 Probechem Biochemicals

Chemical Structure : LDC1267

CAS No.: 1361030-48-9

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LDC1267 (LDC-1267, LDC 1267)

货号: PC-43061Not For Human Use, Lab Use Only.

LDC1267 is a potent, highly selective TAM receptor (Tyro3, Axl and Mer) kinase inhibitor with IC50 of <5 nM/8 nM/29 nM for Tyro3, Axl and Mer, respectively.

规格	价格	库存
10 mg	￥1280	In stock
25 mg	￥1980	In stock
50 mg	￥2980	In stock
100 mg		Get quote
200 mg		Get quote
1 g		Get quote

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生物&药学活性

LDC1267 is a potent, highly selective TAM receptor (Tyro3, Axl and Mer) kinase inhibitor with IC50 of <5 nM/8 nM/29 nM for Tyro3, Axl and Mer, respectively.
LDC1267 displays lower activity against Met, Aurora B, Lck, Src, and CDK8.
LDC1267 abolishes the inhibitory effects of Gas6 stimulation in NK cells, moderately affects cell proliferation in 11 of 95 different cell lines with IC50 of >5 uM.
LDC1267 efficiently enhances anti-metastatic NK cell activity, and rejects tumor metastases without serious cytotoxicity (20 mg/kg, i.p.).

物理化学性质&存储条件

分子量	560.548
分子式	C30H26F2N4O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 42 mg/mL
Chemical Name/SMILES	1H-Pyrazole-3-carboxamide, N-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]-3-fluorophenyl]-4-ethoxy-1-(4-fluoro-2-methylphenyl)-

参考文献

1. Paolino M, et al. Nature. 2014 Mar 27;507(7493):508-12.

LDC1267 (LDC-1267, LDC 1267)

生物&药学活性

物理化学性质&存储条件

参考文献

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LDC1267 (LDC-1267, LDC 1267)

生物&药学活性

物理化学性质&存储条件

参考文献

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