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首页-小分子抑制剂&激动剂-Tyrosine Kinase-TAM Receptor (Tyro3-Axl-Mer)-ONO-7475
ONO-7475

Chemical Structure : ONO-7475

CAS No.: 1646839-59-9

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ONO-7475 (Tamnorzatinib, ONO7475)

货号: PC-73130Not For Human Use, Lab Use Only.

ONO-7475 (Tamnorzatinib) is a potent inhibitor of the TAM receptor tyrosine kinase family (Axl IC50=0.7 nM), inhibits the phosphorylation of AXL and Mer, suppresses the growth of AML with FLT3 mutations.

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5 mg ￥880 In stock
10 mg ￥1280 In stock
25 mg ￥2180 In stock
50 mg ￥3680 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

ONO-7475 (Tamnorzatinib) is a potent inhibitor of the TAM receptor tyrosine kinase family (Axl IC50=0.7 nM), inhibits the phosphorylation of AXL and Mer, suppresses the growth of AML with FLT3 mutations.
ONO-7475 sensitizes AXL-expressing EGFR-mutant NSCLC cells to the EGFR-TKIs osimertinib and dacomitinib.
ONO-7475 suppresses the emergence and maintenance of EGFR-TKI-tolerant cells, suppresses the phosphorylation of AKT, p70S6K, ERK, as well as EGFR.
Combination therapy of ONO-7475 and osimertinib delays regrowth of cell line-derived xenograft tumors.
Osimertinib-acquired resistant cells are insensitive to combined therapy with osimertinib and ONO-7475.

物理化学性质&存储条件

分子量 562.582
分子式 C32H26N4O6
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(5-((6,7-Dimethoxyquinolin-4-yl)oxy)pyridin-2-yl)-2,5-dioxo-1-phenyl-1,2,5,6,7,8-hexahydroquinoline-3-carboxamide

参考文献

1. Okura N, et al. Clin Cancer Res. 2020 May 1;26(9):2244-2256.

2. Ruvolo PP, et al. Haematologica. 2017 Dec;102(12):2048-2057.

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