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首页-小分子抑制剂&激动剂-Tyrosine Kinase-TAM Receptor (Tyro3-Axl-Mer)-PF-07265807
PF-07265807

Chemical Structure : PF-07265807

CAS No.: 2412356-57-9

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PF-07265807 (PF 07265807)

货号: PC-72618Not For Human Use, Lab Use Only.

PF-07265807 (PF 07265807) is a potent, selective dual Axl/Mer inhibitor with IC50 of 6.1 nM, 13.2 nM and 21.6 nM for AXL, MER and TYRO3, respectively.

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10 mg ￥1280 In stock
25 mg ￥2180 In stock
50 mg ￥3580 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

PF-07265807 (PF 07265807) is a potent, selective dual Axl/Mer inhibitor with IC50 of 6.1 nM, 13.2 nM and 21.6 nM for AXL, MER and TYRO3, respectively.
PF-07265807 blocks Axl- and Mer-mediated signal transduction pathways, and inhibits proliferation and migration of Axl- and Mer-overexpressing tumor cells.

物理化学性质&存储条件

分子量 591.57
分子式 C29H27F2N7O5
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-[3-Fluoro-4-[[3-[[(1R)-2-hydroxy-1-methylethyl]amino]-1H-pyrazolo[3,4-b]pyridin-4-yl]oxy]phenyl]-3-(4-fluorophenyl)-1,2,3,4-tetrahydro-1-(1-methylethyl)-2,4-dioxo-5-pyrimidinecarboxamide

参考文献

1. Patent WO2020047184A1 (example 1).

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