AZ14145845 | Axl/Mer inhibitor | Probechem Biochemicals

Chemical Structure : AZ14145845

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AZ14145845 (Dual Axl-Mer inhibitor 32, AZ 14145845)

货号: PC-72617Not For Human Use, Lab Use Only.

AZ14145845 (Dual Axl-Mer inhibitor 32) is a potent, selective dual Axl/Mer inhibitor with pIC50 of 7.0/7.8.

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100 mg		Get quote

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生物&药学活性

AZ14145845 (Dual Axl-Mer inhibitor 32) is a potent, selective dual Axl/Mer inhibitor with pIC50 of 7.0/7.8.
AZ14145845 displays little to no inhibition against Flt-3, and Tyro3 (pIC50<4.5).
AZ14145845 demonstrated dose-dependent in vivo efficacy and target engagement in Mer- and Axl-dependent efficacy models, also shows in vivo efficacy in a preclinical MC38 immuno-oncology model in combination with anti-PD1 antibodies and ionizing radiation.

物理化学性质&存储条件

分子量	561.694
分子式	C32H35N9O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-((3-(4-((dimethylamino)methyl)phenyl)imidazo[1,2-a]pyridin-6-yl)methyl)-N-methyl-5-(3-methyl-5-(1,3,5-trimethyl-1H-pyrazol-4-yl)pyridin-2-yl)-1,3,4-oxadiazol-2-amine

参考文献

1. McCoull W, et al. J Med Chem. 2021 Sep 23;64(18):13524-13539.

AZ14145845 (Dual Axl-Mer inhibitor 32, AZ 14145845)

生物&药学活性

物理化学性质&存储条件

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AZ14145845 (Dual Axl-Mer inhibitor 32, AZ 14145845)

生物&药学活性

物理化学性质&存储条件

参考文献

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