UNC4203 |CAS:1818234-19-3 Probechem Biochemicals

Chemical Structure : UNC4203

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UNC4203 (UNC 4203;UNC-4203)

货号: PC-35790Not For Human Use, Lab Use Only.

UNC4203 (UNC-4203) is a potent, highly selective MerTK with IC50 of 2.4 nM, displays >30- and 4 -foldfold selectivity over Alx (IC50=80 nM) and Tyro3 (IC50=9.1 nM).

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生物&药学活性

UNC4203 (UNC-4203) is a potent, highly selective MerTK with IC50 of 2.4 nM, displays >30- and 4 -foldfold selectivity over Alx (IC50=80 nM) and Tyro3 (IC50=9.1 nM).
UNC4203 display IC50 of 39 nM for FLT-3, inhibits MERTK phosphorylation in cell-based assays with IC50 of 13.8 nM.
UNC4203 inhibits MERTK phosphorylation in vivo in mice with advanced leukemia (30 mg/kg, ip injection).

物理化学性质&存储条件

分子量	504.723
分子式	C30H44N6O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	trans-4-(5-(4-((4-Methyl-1,4-diazepan-1-yl)methyl)phenyl)-2-(((S)-pentan-2-yl)amino)-7Hpyrrolo[2,3-d]pyrimidin-7-yl)cyclohexan-1-ol

参考文献

1. Zhao J, et al. J Med Chem. 2018 Nov 5. doi: 10.1021/acs.jmedchem.8b01229.

UNC4203 (UNC 4203;UNC-4203)

生物&药学活性

物理化学性质&存储条件

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UNC4203 (UNC 4203;UNC-4203)

生物&药学活性

物理化学性质&存储条件

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