UNC5293 | MER inhibitor | Probechem Biochemicals

Chemical Structure : UNC5293

CAS No.: 2226789-82-6

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UNC5293 (UNC-5293)

货号: PC-72649Not For Human Use, Lab Use Only.

UNC5293 (UNC-5293) is a potent, highly selective, orally available inhibitor of MER receptor tyrosine kinase (MERTK) with IC50 0.9 nM, Ki 0.19 nM.

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10 mg	￥1580	In stock
25 mg	￥2580	In stock
50 mg	￥4280	In stock
100 mg		Get quote

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生物&药学活性

UNC5293 (UNC-5293) is a potent, highly selective, orally available inhibitor of MER receptor tyrosine kinase (MERTK) with IC50 0.9 nM, Ki 0.19 nM.
UNC5293 exhibits an excellent Ambit selectivity score (S50 (100 nM) = 0.041), and displays 50-100 fold selectivity over other two TAM Receptor member kinases (Tyro3 and Axl).
UNC5293 demonstrated potent and selective inhibition of MERTK in cell-based assays. has excellent mouse PK properties (7.8 h half-life and 58% oral bioavailability) and was active in bone marrow leukemia cells in a murine model.

物理化学性质&存储条件

分子量	518.706
分子式	C30H42N6O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2,6-dimethylpyridin-4-yl)(4-(7-((1r,4S)-4-hydroxycyclohexyl)-2-(((S)-pentan-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)piperidin-1-yl)methanone

参考文献

1. Zheng H, et al. Eur J Med Chem. 2021 Aug 5;220:113534.

UNC5293 (UNC-5293)

生物&药学活性

物理化学性质&存储条件

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UNC5293 (UNC-5293)

生物&药学活性

物理化学性质&存储条件

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