| Cat. No. |
Product Name |
Information |
| PC-20881 |
PREX-in1
P-Rex inhibitor
|
PREX-in1 is a specific small-molecule inhibitor of P-Rex1 and P-Rex2 Rac-GEF activity with IC50 of 4.5 uM (P-Rex1 DHPH Rac-GEF activity) in liposome-based GEF assay, inhibits P-Rex1 and P-Rex2 through their catalytic DH domain. |
| PC-20183 |
GYS32661
RAC1 inhibitor
|
GYS32661 (GYS 32661) is a potent Rac inhibitor capable of inhibiting both Rac1 and Rac1b, inhibited activated Rac1 with IC50 of 1.18 uM in in vitro pull-down assays. |
| PC-20011 |
Rho GTPase inhibitor O1
Rho inhibitor
|
Rho GTPase inhibitor O1 is a small molecule RhoA GTPase inhibitor, perturbs mitotic progression in fission yeast. |
| PC-49776 |
Phox-I2
p67phox-Rac1 inhibitor
|
Phox-I2 is a specific small molecule inhibitor of Rac1-p67phox interaction, binds to the Rac1 interactive site of p67phox specifically (Ki=150 nM) and interferes with Rac1-GTP interaction with p67phox. |
| PC-49214 |
CS7171
Rac1 inhibitor
|
CS7171 is an effective, blood-brain barrier (BBB) permeable small molecule inhibitor of hippocampal Rac1 activity, rescues learning deficits in APP/PS1 mice. |
| PC-49213 |
JKF-034
Rac1 inhibitor
|
JKF-034 is an effective,blood-brain barrier (BBB) permeable small molecule inhibitor of hippocampal Rac1 activity, rescues learning deficits in APP/PS1 mice. |
| PC-49212 |
EHT1864
Rac inhibitor
|
EHT1864 is a small molecule Rac inhibitor that blocks the Rac1 signaling pathways with IC50 of 5 uM in cellular luciferase assays, binds to Rac1b and Rac2 with very similar affinities (50 and 60 nM, respectively). |
| PC-38721 |
1D-142
RAC1 inhibitor
|
1D-142 is a novel small molecule RHO family of GTPase RAC1 inhibitor, inhibits Rac1-GEF interaction and reduces Rac1-mediated TNFα-induced NF-κB nuclear translocation during cell proliferation and migration. |
| PC-38507 |
RBC10
Ral GTPase inhibitor
|
RBC10 is a small molecule that target the Ral GTPase, inhibits Ral binding to its effector RalBP1, Ral-mediated cell spreading in murine fibroblasts and anchorage-independent growth of human cancer cell lines. |
| PC-38415 |
ARN22089
Cdc42 inhibitor
|
ARN22089 (ARN 22089) is a specific small molecule inhibitor of putative CDC42 family effector interaction, binds to CDC42 and has broad anti-cancer activity and inhibits MAPK and S6 signaling. |
| PC-36078 |
Bragsin2
BRAG2 inhibitor
|
Bragsin2 (Bragsin 2) is a specific inhibitor of the ArfGEF BRAG2, affects the trans-Golgi network in a BRAG2- and Arf-dependent manner in cells (IC50=3 uM). |
| PC-36077 |
Bragsin1
BRAG2 inhibitor
|
Bragsin1 (Bragsin 1) is a specific inhibitor of the ArfGEF BRAG2, affects the trans-Golgi network in a BRAG2- and Arf-dependent manner in cells (IC50=3 uM). |
