| Cat. No. |
Product Name |
Information |
| PC-63530 |
ML099
Rho-family GTPases activator
|
ML099 (CID888706) is a small molecule, pan activator of Rho-family GTPases, activates Rac1, cell division cycle 42, Ras, Rab7, and Rab-2A |
| PC-63241 |
Z62954982
Rac1 inhibitor
|
Z62954982 is a potent, specific Rac1 inhibitor, reduces the intracellular levels of Rac1-GTP in a concentration-dependent manner with IC50 of 12 uM, 4 times more effective than NSC23766 (IC50=50 uM). |
| PC-43277 |
CASIN
Cdc42 inhibitor
|
CASIN is a specific inhibitor of small RhoGTPase Cdc42, inhibits PIP2-stimulated actin polymerization in Xenopus egg extracts with IC50 of 2 uM. |
| PC-43278 |
BQU57
Ral inhibitor
|
BQU57 is a specific small molecule inhibitor of GTPase Ral, inhibits both RalA and RalB activation and colony formation of Ral-dependent lines H2122 and H358 in soft agar with IC50 of 2.0 and 1.3 uM, respectively. |
| PC-43276 |
RBC8
GTPase Ral inhibitor
|
RBC8 is a specific small molecule inhibitor of GTPase Ral, inhibits both RalA and RalB activation and colony formation of Ral-dependent lines H2122 and H358 in soft agar with IC50 of 3.5 and 3.4 uM, respectively. |
| PC-43223 |
EHop-016
Rac inhibitor
|
EHop-016 is a specific Rac GTPase inhibitor with IC50 of 1.1 uM, which is 100-fold lower than for NSC23766, EHop-016 is specific for Rac1 and Rac3 at <5 uM. |
| PC-43180 |
ML141
Cdc42 inhibitor
|
ML141 (CID-2950007) is a potent, selective, reversible non-competitive inhibitor of Cdc42 GTPase with IC50 of 200 nM in biochemical assays, shows no appreciable inhibitory activity against Rac1, Rab2, Rab7 or Ras. |
| PC-43137 |
Y16
RhoA-LARG inhibitor
|
Y16 (RhoA-LARG inhibitor Y16) is a small-molecule inhibitor that specifically inhibits LARG binding to RhoA, binds to the junction site of the DH-PH domains of LARG with Kd of 80 nM. |
| PC-43133 |
Rhosin
RhoA inhibitor
|
Rhosin (G04) is a potent, specific RhoA subfamily Rho GTPases inhibitor that specifically binds to RhoA to inhibit GEF reaction of RhoA with Kd of 0.4 uM, does not interact with Cdc42 or Rac1, nor the LARG. |
| PC-43132 |
Rhosin hydrochloride
RhoA inhibitor
|
Rhosin (G04) is a potent, specific RhoA subfamily Rho GTPases inhibitor that specifically binds to RhoA to inhibit GEF reaction of RhoA with Kd of 0.4 uM, does not interact with Cdc42 or Rac1, nor the LARG. |
| PC-62791 |
BQU-082
GTPase Ral inhibitor
|
BQU-082 is a novel potent small GTPase Ral (Ras-like) inhibitor with IC50 of 1.7 uM, displays a dose dependent effect on RalA and RalB activity in H2122 spheroids using the common RalBP1 pull-down assay. |
| PC-62562 |
TBOPP
DOCK1 inhibitor
|
TBOPP is a selective inhibitor of Rac-specific guanine nucleotide exchange factor DOCK1, inhibits DOCK1-mediated Rac activation with IC50 of 8.4 uM. |
