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首页-小分子抑制剂&激动剂-Others-Small GTPase-ARN25499
ARN25499

Chemical Structure : ARN25499

CAS No.:

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ARN25499 (ARN-25499)

货号: PC-22520Not For Human Use, Lab Use Only.

ARN25499 is a potent, selective inhibitor of CDC42 GTPases (CDC42, RHOJ, RHOQ), exhibits s antiproliferative activity of melanoma cancer cell lines that have a BRAFV600E mutation (SKM28, SKMel3, WM3248, A375) with IC50 of 8-13.5 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

ARN25499 is a potent, selective inhibitor of CDC42 GTPases (CDC42, RHOJ, RHOQ), exhibits s antiproliferative activity of melanoma cancer cell lines that have a BRAFV600E mutation (SKM28, SKMel3, WM3248, A375) with IC50 of 8-13.5 uM.
ARN25499 shows improved in vitro metabolic stability compared to ARN22089 and ARN25062.
ARN25499 (10 mg/kg, injected via tail vein) slows the growth of melanoma PDX tumors in NSG mice.

物理化学性质&存储条件

分子量 390.49
分子式 C23H26N4O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(3,4-dimethoxyphenyl)-4-phenyl-6-(piperidin-4-yl)pyrimidin-2-amine

参考文献

1. Brindani N, et al. J Med Chem. 2024 Jun 12. doi: 10.1021/acs.jmedchem.4c00855.

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