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首页-小分子抑制剂&激动剂-Others-Small GTPase-ARN24928
ARN24928

Chemical Structure : ARN24928

CAS No.: 3036492-84-6

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ARN24928 (ARN-24928)

货号: PC-22521Not For Human Use, Lab Use Only.

ARN24928 is a potent, selective inhibitor of CDC42 GTPases (CDC42, RHOJ, RHOQ), exhibits s antiproliferative activity of melanoma cancer cell lines that have a BRAFV600E mutation (SKM28, SKMel3, WM3248, A375) with IC50 of 3.2-6.9 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

ARN24928 is a potent, selective inhibitor of CDC42 GTPases (CDC42, RHOJ, RHOQ), exhibits s antiproliferative activity of melanoma cancer cell lines that have a BRAFV600E mutation (SKM28, SKMel3, WM3248, A375) with IC50 of 3.2-6.9 uM.
ARN24928 (10 mg/kg) significantly inhibits tumor growth in the PDX model.

物理化学性质&存储条件

分子量 374.49
分子式 C22H26N6
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N1,N1-dimethyl-N3-(4-phenyl-6-(piperidin-4-yl)-1,3,5-triazin-2-yl)benzene-1,3-diamine

参考文献

1. Brindani N, et al. J Med Chem. 2023 Apr 27;66(8):5981-6001.

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