DU101 | Arf1 inhibitor | Probechem Biochemicals

Chemical Structure : DU101

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DU101 (DU-101)

货号: PC-23015Not For Human Use, Lab Use Only.

DU101 is a potent small molecule inhibitor of small G protein Arf1, binds to the catalytic pocket of the Arf1-GDP-Sec7, inhibit Arf1 activity by binding to Arf1 and Arf-GEF.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

DU101 is a potent small molecule inhibitor of small G protein Arf1, binds to the catalytic pocket of the Arf1-GDP-Sec7, inhibit Arf1 activity by binding to Arf1 and Arf-GEF.
DU101 dramatically reduced the mitochondrial membrane potential in CT26 cells, also promote cell aging cascade in cancer stem cells (CSCs).
DU101 promotes T cell infiltration, activation, and memory T cell population, does not directly kill tumor cells rather than enhances anti-tumor immunity. DU101 inflames the tumor microenvironment, reprogrammes CD8+ T cells into more activated T cells with elevated effector function, reduced exhaustion, increased proliferation, and stronger cytotoxic activity.
DU101 promotes a population of PD-1+TCF1+CD8+ CD4+ stem-like T cells in liver tumors.
DU101 exhibits low toxicity and robust anti-tumor activities in various mouse tumor models, including liver, colon, breast, and melanoma, as well as PDX tumor models.

物理化学性质&存储条件

分子量	347.44
分子式	C19H17N5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-4-(2-((1H-indol-5-yl)methylene)hydrazineyl)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine

参考文献

1. Yuetong Wang, et al. Adv Sci (Weinh). 2024 Sep 3:e2404442.

DU101 (DU-101)

生物&药学活性

物理化学性质&存储条件

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DU101 (DU-101)

生物&药学活性

物理化学性质&存储条件

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