Phox-I2

Chemical Structure : Phox-I2

CAS No.: 353495-22-4

加入收藏

货号: PC-49776Not For Human Use, Lab Use Only.

Phox-I2 is a specific small molecule inhibitor of Rac1-p67phox interaction, binds to the Rac1 interactive site of p67phox specifically (Ki=150 nM) and interferes with Rac1-GTP interaction with p67phox.

规格	价格	库存
5 mg	￥1580	In stock
10 mg	￥2380	In stock
25 mg	￥3880	In stock
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

Phox-I2 is a specific small molecule inhibitor of Rac1-p67phox interaction, binds to the Rac1 interactive site of p67phox specifically (Ki=150 nM) and interferes with Rac1-GTP interaction with p67phox.
Phox-I2 is active in suppressing ROS production in both human and murine neutrophils.
Phox-I2 is effective in inhibiting NOX2-mediated superoxide production dose-dependently in human and murine neutrophils without detectable toxicity.
Phox-I2 inhibitedcollagen-induced platelet aggregation without affecting the tail bleeding time, inhibited in vivo platelet adhesion/accumulation at the laser injury sites on the saphenous vein without affecting the time for complete cessation of blood loss.

物理化学性质&存储条件

分子量	337.34
分子式	C18H15N3O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3a,4,5,9b-Tetrahydro-8-nitro-4-(3-nitrophenyl)-3H-cyclopenta[c]quinoline

参考文献

1. Emily E Bosco, et al. Chem Biol. 2012 Feb 24;19(2):228-42.

2. H Akbar, et al. J Thromb Haemost. 2018 Oct;16(10):2083-2096.

Phox-I2

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Phox-I2

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.