AH001 | RhoA inhibitor, TRPV4 inhibitor | Probechem Biochemicals

Chemical Structure : AH001

加入收藏

AH001 (AH-001)

货号: PC-26834Not For Human Use, Lab Use Only.

AH001 is a potent, specific inhibitor of RhoA signaling pathway by targeting the TRPV4-RhoA-RhoGDI1 axis, targets not only the RhoGDI1-RhoA complex, but also TRPV4.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

AH001 is a potent, specific inhibitor of RhoA signaling pathway by targeting the TRPV4-RhoA-RhoGDI1 axis, targets not only the RhoGDI1-RhoA complex, but also TRPV4.
AH001 significantly inhibits GSK1016790A-stimulated calcium influx.
AH001 inactivates RhoA by stabilizing the TRPV4-RhoA interaction and RhoGDI1-Rho A interaction.
AH001 relieves blood pressure in hypertension model of Ang II–induced mice.
AH001 relieves blood pressure in hypertension model of SHR rats.
AH001 attenuates smooth muscle contraction and phenotypic transformation, and effectively lowering blood pressure after both acute and chronic administration in hypertensive animal models.

物理化学性质&存储条件

分子量	166.22
分子式	C10H14O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-1-(3-ethylphenyl) ethane-1,2-diol

参考文献

1. Jiawen Wang, et al. Circulation. 2025 Aug 26;152(8):519-536.

AH001 (AH-001)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

AH001 (AH-001)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.