SCC944 (MCULE-5095997944) | ARF1 inhibitor, ARF1-CSW modulator

Chemical Structure : SCC944

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SCC944 (MCULE-5095997944, SCC-944)

货号: PC-27291Not For Human Use, Lab Use Only.

SCC944 (MCULE-5095997944) is a small molecule ARF1-CSW modulator, binds directly to ARF1 (SPR KD=167 nM) and reduces GTP-bound ARF1 levels upon ARF1 activation.

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生物&药学活性

SCC944 (MCULE-5095997944) is a small molecule ARF1-CSW modulator, binds directly to ARF1 (SPR KD=167 nM) and reduces GTP-bound ARF1 levels upon ARF1 activation.
SCC944 antagonizes ARF1 activation, significantly suppresses the active GTP-bound ARF1 levels.
SCC944 interacts with various residues in ARF1, SMCR8, and C9orf72 proteins.
SCC944 demonstrated brefeldin A-like ARF1-dependent alteration of organelle organization including Golgi, microtubules, and mitochondria, but also a protein trafficking pattern that is distinct from brefeldin A mechanism.
The C9orf72 protein forms a complex with SMCR8 and WDR41 (CSW), which functions as a GTPase-activating protein (GAP) regulating ARF1 and RAB small GTPases.

物理化学性质&存储条件

分子量	368.78
分子式	C18H13ClN4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-N-(4-chlorophenyl)-2-oxo-2-(2-((2-oxo-1,2-dihydroquinolin-3-yl)methylene)hydrazineyl)acetamide

参考文献

1. Dixon E, et al. bioRxiv [Preprint]. 2026 Jul 1:2026.01.24.701325.

SCC944 (MCULE-5095997944, SCC-944)

生物&药学活性

物理化学性质&存储条件

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SCC944 (MCULE-5095997944, SCC-944)

生物&药学活性

物理化学性质&存储条件

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