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DU102

Chemical Structure : DU102

CAS No.: 2468014-78-8

DU102 (DU-102)

货号: PC-23016Not For Human Use, Lab Use Only.

DU102 is a potent small molecule inhibitor of small G protein Arf1, binds to the catalytic pocket of the Arf1-GDP-Sec7, inhibit Arf1 activity by binding to Arf1 and Arf-GEF.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

DU102 is a potent small molecule inhibitor of small G protein Arf1, binds to the catalytic pocket of the Arf1-GDP-Sec7, inhibit Arf1 activity by binding to Arf1 and Arf-GEF.
DU102 dramatically reduced the mitochondrial membrane potential in CT26 cells, also promote cell aging cascade in cancer stem cells (CSCs).
DU102 promotes T cell infiltration, activation, and memory T cell population, does not directly kill tumor cells rather than enhances anti-tumor immunity. DU102 inflames the tumor microenvironment, reprogrammes CD8+ T cells into more activated T cells with elevated effector function, reduced exhaustion, increased proliferation, and stronger cytotoxic activity.
DU102 promotes a population of PD-1+TCF1+CD8+ CD4+ stem-like T cells in liver tumors.
DU102 exhibits low toxicity and robust anti-tumor activities in various mouse tumor models, including liver, colon, breast, and melanoma, as well as PDX tumor models.

物理化学性质&存储条件

分子量 375.49
分子式 C21H21N5S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(E)-4-(2-((1H-indol-5-yl)methylene)hydrazineyl)-5,6,7,8,9,10-hexahydrocycloocta[4,5]thieno[2,3-d]pyrimidine

参考文献

1. Yuetong Wang, et al. Adv Sci (Weinh). 2024 Sep 3:e2404442.

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