RAC1 inhibitor A41

Chemical Structure : RAC1 inhibitor A41

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货号: PC-24945Not For Human Use, Lab Use Only.

RAC1 inhibitor A41 is a potent, specific and reversible inhibitor of RAC proteins, competes with guanine nucleotide binding, inhibits RAC1-dependent membrane ruffle formation with IC50 of 2.5 nM.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

RAC1 inhibitor A41 is a potent, specific and reversible inhibitor of RAC proteins, competes with guanine nucleotide binding, inhibits RAC1-dependent membrane ruffle formation with IC50 of 2.5 nM.
A41 (10 uM) blocks RAC1 activation in EGF-stimulated NIH/3T3 fibroblasts.
A41 is not RAC-GEF dependent.
A41 (10 uM) reduced TRIO-induced activation of RAC2, which is closely related to RAC1, but had no effect on TRIO-induced RHOG activation.
A41 directly interacts with RAC1 (SPR KD = 30 nM), shows no affinity for RHOA and CDC42.
A41 inhibits RAC1 activity and oncogenic properties of TNBC cell line, decreases growth and invasiveness of TNBC cells in vitro.
A41 (25 mg/kg/day, i.p.) prevents metastasis in a mouse model of TNBC.

物理化学性质&存储条件

分子量	486.60
分子式	C24H26N2O5S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-(N-(2,5-dimethoxyphenyl)sulfamoyl)phenyl)-3-(p-tolylthio)propanamide

参考文献

1. Dilasser F, et al. Cell Rep Med. 2025 Jun 28:102233.