MAR-3.6.2

Chemical Structure : MAR-3.6.2

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货号: PC-26550Not For Human Use, Lab Use Only.

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生物&药学活性

MAR-3.6.2 is a specific small molecule, allosteric inhibitor of small GTPase RAN (RAS-related nuclear protein), targets RAN a cryptic pocket and disrupts its on-state and nuclear export, decreases miR-126 biogenesis.
MAR-3.6.2 reduces RAN GTP binding in HUVEC ECS.
MAR-3.6.2 has no measurable impact on the GTP-binding activity of related small GTPases, including RAS and RAB5.
MAR-3.6.2 disrupted RAN interaction with RCC1 and trapped RAN-GDP in the nucleus, decreased nucleus-to-cytoplasm export of pre-miR-126 and mature miR-126 biogenesis.
MAR-3.6.2 demonstrated dose-dependent inhibition of cell proliferation and induction of apoptosis across multiple AML cell lines.
MAR-3.6.2 (25 mg/kg, IV, daily for 3 weeks) exhibited significant antileukemic activity in the MllPTD/WT/Flt3ITD/ITD AML mouse model.

物理化学性质&存储条件

分子量	372.44
分子式	C19H20N2O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3,8-dimethyl-3-(2-(o-tolylamino)thiazol-4-yl)-2,7-dioxaspiro[4.4]nonane-1,6-dione

参考文献

1. Valerio M, et al. Commun Biol. 2026 Apr 14. doi: 10.1038/s42003-026-10026-0.

MAR-3.6.2

生物&药学活性

物理化学性质&存储条件

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MAR-3.6.2

生物&药学活性

物理化学性质&存储条件

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