Polo-like Kinase (PLK) compound (inhibitors, antagonists, modulators)-ProbeChem.com

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Cat. No.	Product Name	Information
PC-45847	BI-2536 PLK1 inhibitor	BI-2536 is a potent and selective inhibitor of PLK1 with IC50 of 0.83 nM.
PC-42779	GW843682X PLK1/3 inhibitor	GW843682X is a potent and selective inhibitor of PLK1 (IC5=2.2 nM) and PLK3 (IC50=9 nM).
PC-24271	IIP0943 PLK1 inhibitor	IIP0943 is a highly potent, selective polo-like kinase 1 (PLK1) inhibitor with IC50 of 5.1 nM, exhibits high selectivity for PLK1 compared to other PLKs.
PC-24098	HMN-176 PLK1 inhibitor	HMN-176 is an active metabolite of HMN-214 and inhibitor of mitosis, interferes with the subcellular spatial location of PLK1, does not inhibit PLK directly.
PC-24019	PLK1 inhibitor B31 PLK1 inhibitor	PLK1 inhibitor B31 is a potent, highly selective and orally active inhibitor of polo-like kinase 1 (PLK1) with IC50 of 20 nM, >200-fold selective over PLK2/PLK3.
PC-23368	TC-S 7005 PLK2 inhibitor	TC-S 7005 is a potent, selective polo-like kinase 2 (PLK2) inhibitor with IC50 of 4 nM, 24 nM and 214 nM for PLK2, PLK3, and PLK1, respectively.
PC-21170	SBE13 PLK1 inhibitor	PLK1 inhibitor SBE13 is a potent, selective PLK1 inhibitor with IC50 of 0.2 nM, with little to no inhibition against PLK2/PLK3 (IC50, 65 uM/875 nM).
PC-21169	Ro3280 PLK1 inhibitor	Ro3280 is a potent, specific PLK1 inhibitor with IC50/Kd of 3/0.09 nM, respectively, shows no activity against PLK2/3.

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