| Cat. No. |
Product Name |
Information |
| PC-61201 |
Poloppin II
PLK1 inhibitor
|
Poloppin II is an orally active, Poloppin derivative inhibitor of protein-protein interaction via the PBD of the mitotic Polo-like kinase (PLK) with IC50 of 41 uM in FP assays, exhibits IC50 of 61 nM cellular assay for mitotic arrest. |
| PC-61200 |
Poloppin
PLK1 inhibitor
|
Poloppin is a cell-active, small molecule inhibitor of protein-protein interaction via the Polo-box domain (PBD) of the mitotic Polo-like kinase (PLK) with IC50 of 26.9 uM (PLK1) in FP assays. |
| PC-60180 |
Poloxin-2
PLK1 inhibitor
|
Poloxin-2 (Poloxin 2) is a potent, selective PLK1 PBD inhibitor with IC50 of 1.36 uM. |
| PC-45981 |
Poloxime
PLK1 inhibitor
|
Poloxime is an analog of thymoquinone that blocks pSer/pThr recognition by Plk1 Polo-box domain (PLK1 PBD) as a phosphate mimic. |
| PC-45524 |
Centrinone B
PLK4 inhibitor
|
Centrinone B (LCR-323) is a selective, reversible PLK4 inhibitor with Ki of 0.6 nM in vitro. |
| PC-45523 |
Centrinone
PLK4 inhibitor
|
Centrinone (LCR-263) is a selective, reversible PLK4 inhibitor with Ki of 0.16 nM in vitro. |
| PC-45884 |
GSK461364
PLK1 inhibitor
|
GSK461364 (GSK-461364) is a potent, selective, and reversible ATP-competitive PLK1 inhibitor with Ki of 2.2 nM. |
| PC-45847 |
BI-2536
PLK1 inhibitor
|
BI-2536 is a potent and selective inhibitor of PLK1 with IC50 of 0.83 nM. |
| PC-42779 |
GW843682X
PLK1/3 inhibitor
|
GW843682X is a potent and selective inhibitor of PLK1 (IC5=2.2 nM) and PLK3 (IC50=9 nM). |
| PC-27575 |
Abbapolin 8
PLK1 PBD inhibitor
|
Abbapolin 8 is a specific, non-peptidic inhibitor of PLK1 Polo-box domain (PBD), directly engages PLK1 in cells, induces selective degradation of endogenous PLK1. |
| PC-27574 |
Abbapolin 6
PLK1 PBD inhibitor
|
Abbapolin 6 is a specific, non-peptidic inhibitor of PLK1 Polo-box domain (PBD), directly engages PLK1 in cells, induces selective degradation of endogenous PLK1. |
| PC-27199 |
PLK1 inhibitor B9
PLK1 inhibitor
|
PLK1 inhibitor B9 is a potent, selective, covalent inhibitor of polo-like kinase 1 (PLK1) with IC50 of 19 nM, shows exceptional cellular potency with IC50 of 0.4 nM in K562 leukemia cells. |
