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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-Polo-like Kinase (PLK)-Centrinone
Centrinone

Chemical Structure : Centrinone

CAS No.: 1798871-30-3

Centrinone (LCR-263, LCR263)

货号: PC-45523Not For Human Use, Lab Use Only.

Centrinone (LCR-263) is a selective, reversible PLK4 inhibitor with Ki of 0.16 nM in vitro.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Centrinone (LCR-263) is a selective, reversible PLK4 inhibitor with Ki of 0.16 nM in vitro.
Centrinone (LCR-263) causes centrosome depletion at 100 nM in human and other vertebrate cells.
Centrinone (LCR-263) shows >1000-fold selectivity over Aurora A and Aurara B; leads to irreversible, p53-dependent G1 arrest by an unknown mechanism.

物理化学性质&存储条件

分子量 633.6468
分子式 C26H25F2N7O6S2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: ≥ 31 mg/mL

Chemical Name/SMILES

4-Pyrimidinamine, 2-[[2-fluoro-4-[[(2-fluoro-3-nitrophenyl)methyl]sulfonyl]phenyl]thio]-5-methoxy-N-(5-methyl-1H-pyrazol-3-yl)-6-(4-morpholinyl)-

参考文献

1. Wong YL, et al. Science. 2015 Jun 5;348(6239):1155-60.

2. Meitinger F, et al. J Cell Biol. 2016 Jul 18;214(2):155-66.

3. Guizzunti G, et al. Proc Natl Acad Sci U S A. 2016 Oct 25;113(43):E6590-E6599.

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