| Cat. No. |
Product Name |
Information |
| PC-62790 |
PLK1-IN-14f
PLK1 inhibitor
|
PLK1-IN-14f is a potent PLK1 inhibitor, exhibits potent activity against a panel cancer cell lines with GI50 values ranging from 0.30 to 0.60 uM. |
| PC-62393 |
Poloxin
PLK1 inhibitor
|
Poloxin is the first reported PLK1 PBD inhibitor with IC50 of 6.4 uM, shows less potent inhibition for Plk2 PBD and Plk3 PBD. |
| PC-62159 |
Cyclapolin 1
PLK1 inhibitor
|
Cyclapolin 1 is a potent and selective PLK1 inhibitor that promotes loss of centrosome integrity and microtubule nucleating ability apparently through increased accessibility of protein phosphatases. |
| PC-62158 |
Cyclapolin 9
PLK1 inhibitor
|
Cyclapolin 9 is a potent, selective, and ATP-competitive polo-like kinase PLK1 inhibitor with IC50 of 500 nM. |
| PC-61201 |
Poloppin II
PLK1 inhibitor
|
Poloppin II is an orally active, Poloppin derivative inhibitor of protein-protein interaction via the PBD of the mitotic Polo-like kinase (PLK) with IC50 of 41 uM in FP assays, exhibits IC50 of 61 nM cellular assay for mitotic arrest. |
| PC-61200 |
Poloppin
PLK1 inhibitor
|
Poloppin is a cell-active, small molecule inhibitor of protein-protein interaction via the Polo-box domain (PBD) of the mitotic Polo-like kinase (PLK) with IC50 of 26.9 uM (PLK1) in FP assays. |
| PC-60180 |
Poloxin-2
PLK1 inhibitor
|
Poloxin-2 (Poloxin 2) is a potent, selective PLK1 PBD inhibitor with IC50 of 1.36 uM. |
| PC-45981 |
Poloxime
PLK1 inhibitor
|
Poloxime is an analog of thymoquinone that blocks pSer/pThr recognition by Plk1 Polo-box domain (PLK1 PBD) as a phosphate mimic. |
| PC-45524 |
Centrinone-B
PLK4 inhibitor
|
Centrinone-B (LCR-323) is a selective, reversible PLK4 inhibitor with Ki of 0.6 nM in vitro. |
| PC-45523 |
Centrinone
PLK4 inhibitor
|
Centrinone (LCR-263) is a selective, reversible PLK4 inhibitor with Ki of 0.16 nM in vitro. |
| PC-45884 |
GSK461364
PLK1 inhibitor
|
GSK461364 is a potent, selective, and reversible ATP-competitive PLK1 inhibitor with Ki of 2.2 nM. |
| PC-45847 |
BI-2536
PLK1 inhibitor
|
BI-2536 is a potent and selective inhibitor of PLK1 with IC50 of 0.83 nM. |
