T-521 |CAS:891020-54-5 Probechem Biochemicals

首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-Polo-like Kinase (PLK)-T-521

Chemical Structure : T-521

CAS No.: 891020-54-5

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T-521 (PLK1 PBD inhibitor T521)

货号: PC-63063Not For Human Use, Lab Use Only.

T-521 is a novel PLK1 PBD (Polo-box domain) inhibitor that specifically inhibits the PBD of PLK1 (IC50=1.22 uM), but not those of Plk2-3.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

T-521 is a novel PLK1 PBD (Polo-box domain) inhibitor that specifically inhibits the PBD of PLK1 (IC50=1.22 uM), but not those of Plk2-3.
T-521 impedes the interaction between Plk1 and Bub1, exhibits dramatic mitotic defects in HeLa cells.
T-521 suppresses the growth of A549 cells in xenograft nude mice.

物理化学性质&存储条件

分子量	512.43
分子式	C26H27Cl2N5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-(ethylsulfonyl)-2-(4-fluorophenyl)-4-(phenylsulfonyl)oxazole

参考文献

1. Chen Y, et al. Oncotarget. 2017 Jan 3;8(1):1234-1246.

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T-521 (PLK1 PBD inhibitor T521)

生物&药学活性

物理化学性质&存储条件

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T-521 (PLK1 PBD inhibitor T521)

生物&药学活性

物理化学性质&存储条件

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