MCC1019 | PLK1 PBD inhibitor | Probechem Biochemicals

Chemical Structure : MCC1019

加入收藏

MCC1019 (MCC 1019)

货号: PC-20477Not For Human Use, Lab Use Only.

MCC1019 is a selective inhibitor of PLK1, targets PLK1 Polo box domain (PBD) with binding IC50 of 16.4 uM, 2.75-fold over PLK2-PBD (IC50=44.1 uM) and > 6-fold higher specificity over PLK3 PBD (IC50 >100 uM).

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

MCC1019 is a selective inhibitor of PLK1, targets PLK1 Polo box domain (PBD) with binding IC50 of 16.4 uM, 2.75-fold over PLK2-PBD (IC50=44.1 uM) and > 6-fold higher specificity over PLK3 PBD (IC50 >100 uM).
MCC1019 exerted profound cytotoxicity across a panel of cancer cell lines, hematologic malignancies (CCRF-CEM, K562 and CEM/ADR5000) were more sensitive to MCC1019 (IC50s <2 uM).
MCC1019 inhibit downstream effector proteins of PLK1 (BUBR1, p-AKT, p-FOXO1 and HIF-1α), induced M phase cell cycle arrest, and apoptosis and necroptosis.
MCC1019 (20 and 40 mg/kg) significantly inhibited tumor growth in LLC-1 lung tumor bearing mice and RM-1 prostate tumor bearing mice models.

物理化学性质&存储条件

分子量	283.12
分子式	C12H11BrO3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	ethyl 3-(bromomethyl)benzofuran-2-carboxylate

参考文献

1. Abdelfatah S, et al. Acta Pharm Sin B. 2019 Sep;9(5):1021-1034.

MCC1019 (MCC 1019)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

MCC1019 (MCC 1019)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.