Rigosertib sodium |CAS:592542-60-4 Probechem Biochemicals

Chemical Structure : Rigosertib sodium

CAS No.: 592542-60-4

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Rigosertib sodium (ON-01910 sodium;ON01910 sodium;ON01910 sodium)

货号: PC-42851Not For Human Use, Lab Use Only.

Rigosertib sodium (ON 01910.Na) is a potent, non-ATP-competitive PLK1 inhibitor (IC50=9-10 nM), selectively induces mitotic G2/M arrest and apoptosis in cancer cells.

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25 mg	￥1580	In stock
50 mg	￥2580	In stock
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生物&药学活性

Rigosertib sodium (ON 01910.Na) is a potent, non-ATP-competitive PLK1 inhibitor (IC50=9-10 nM), selectively induces mitotic G2/M arrest and apoptosis in cancer cells.
Rigosertib also exhibits inhibitory activity against PDGFR, Abl, and Flt-1, at higher concentrations, inhibits CDK1, Plk2, Src, and Fyn.
Rigosertib demonstrates in vitro cytotoxicity against DU145 and K562 cells with IC50 of 100 and 15 nM.
Rigosertib potently inhibits tumor growth in a variety of xenograft nude mouse models, does not exhibit hematotoxicity, liver damage, or neurotoxicity shows strong synergy with several chemotherapeutic agents.

物理化学性质&存储条件

分子量	473.4719
分子式	C21H24NNaO8S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	H2O: ≥ 52 mg/mL
Chemical Name/SMILES	Glycine, N-[2-methoxy-5-[[[(1E)-2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonyl]methyl]phenyl]-, sodium salt (1:1)

参考文献

1. Reddy MV, et al. J Med Chem. 2011 Sep 22;54(18):6254-76.

2. Gumireddy K, et al. Cancer Cell. 2005 Mar;7(3):275-86.

3. Oussenko IA, et al. Cancer Res. 2011 Jul 15;71(14):4968-76.

4. Chun AW, et al. Cancer Chemother Pharmacol. 2009 Dec;65(1):177-86.

Rigosertib sodium (ON-01910 sodium;ON01910 sodium;ON01910 sodium)

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Rigosertib sodium (ON-01910 sodium;ON01910 sodium;ON01910 sodium)

生物&药学活性

物理化学性质&存储条件

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