| Cat. No. |
Product Name |
Information |
| PC-28563 |
EXEL-1855
PLK4 inhibitor
|
EXEL-1855 is a potent, selective and orally bioavailable Polo-like kinase 4 (PLK4) inhibitor with IC50 of 7.7 nM in ADPGlo assays and EC50 of 33 nM in Nano BRET assays. |
| PC-28543 |
CFI-400437 dihydrochloride
PLK4 inhibitor
|
CFI-400437 dihydrochloride is a potent and selective inhibitors of Polo-like kinase 4 (PLK4) with IC50 of 0.6 nM. |
| PC-28269 |
CZS-241 hydrochloride
PLK4 inhibitor
|
CZS-241 hydrochloride is a potent, selective PLK4 inhibitor with IC50 of 2.6 nM for PLK4, >1000-fold selective over TRKA. |
| PC-27575 |
Abbapolin 8
PLK1 PBD inhibitor
|
Abbapolin 8 is a specific, non-peptidic inhibitor of PLK1 Polo-box domain (PBD), directly engages PLK1 in cells, induces selective degradation of endogenous PLK1. |
| PC-27574 |
Abbapolin 6
PLK1 PBD inhibitor
|
Abbapolin 6 is a specific, non-peptidic inhibitor of PLK1 Polo-box domain (PBD), directly engages PLK1 in cells, induces selective degradation of endogenous PLK1. |
| PC-27199 |
PLK1 inhibitor B9
PLK1 inhibitor
|
PLK1 inhibitor B9 is a potent, selective, covalent inhibitor of polo-like kinase 1 (PLK1) with IC50 of 19 nM, shows exceptional cellular potency with IC50 of 0.4 nM in K562 leukemia cells. |
| PC-27091 |
PLK3-IN-1
PLK3 inhibitor
|
PLK3-IN-1 is a potent, isoform-selective PLK3 inhibitor with IC50 of 5 nM, has 1000- and 60-fold selectivity over PLK1 and PLK2. |
| PC-25891 |
CZS-089
PLK4 inhibitor
|
CZS-089 is a potent, selective PLK4 inhibitor with IC50 of 26 nM. |
| PC-25889 |
CZS-034
PLK4 inhibitor
|
CZS-034 is a highly potent. selective PLK4 inhibitor with IC50 of 0.2 nM, exhibits antiproliferative activities against MCF-7, BT474, and MDA-MB-231 cells with IC50 of 0.36, 1.35, and 2.88 uM respectively. |
| PC-25888 |
CZS-035
PLK4 inhibitor
|
CZS-035 is a potent, selective PLK4 inhibitor with binding IC50 of 0.7 nM for PLK4, shows strong antiproliferative activity on MCF-7 cells with IC50 of 0.65 uM. |
| PC-25813 |
TAK-960
PLK1 inhibitor
|
TAK-960 is a potent, selective, ATP-competitive, orally available inhibitor of polo-like kinase 1 (PLK1) with IC50 of 1.6 nM in TR-FRET assays. |
| PC-24600 |
PLK1 inhibitor B4
PLK1 inhibitor
|
PLK1 inhibitor B4 is a novel small molecule inhibitor of polo-like kinase 1 (PLK1) with SPR KD of 5.6 uM, IC50 of 13.52 uM. |
