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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-Polo-like Kinase (PLK)-CZS-034
CZS-034

Chemical Structure : CZS-034

CAS No.: 2923998-95-0

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CZS-034 (CZS034)

货号: PC-25889Not For Human Use, Lab Use Only.

CZS-034 is a highly potent. selective PLK4 inhibitor with IC50 of 0.2 nM, exhibits antiproliferative activities against MCF-7, BT474, and MDA-MB-231 cells with IC50 of 0.36, 1.35, and 2.88 uM respectively.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

CZS-034 is a highly potent. selective PLK4 inhibitor with IC50 of 0.2 nM, exhibits antiproliferative activities against MCF-7, BT474, and MDA-MB-231 cells with IC50 of 0.36, 1.35, and 2.88 uM respectively.

物理化学性质&存储条件

分子量 440.46
分子式 C21H22F2N8O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N6-(2,4-difluorobenzyl)-N4-(5-methyl-1H-pyrazol-3-yl)-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-d]pyrimidine-4,6-diamine

参考文献

1. Yin Sun, et al. Eur J Med Chem. 2022 Aug 5:238:114424.

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