Volasertib (BI-6727) | PLK inhibitor | Probechem Biochemicals

Chemical Structure : Volasertib

CAS No.: 755038-65-4

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Volasertib (BI 6727, BI-6727, BI6727)

货号: PC-42899Not For Human Use, Lab Use Only.

Volasertib (BI 6727) is a potent, selective Polo-like kinase (PLK) inhibitor with IC50 of 0.87, 5 and 56 nM for PLK1, 2 and 3, respectively.

规格	价格	库存
10 mg	￥1180	In stock
25 mg	￥1980	In stock
50 mg	￥2980	In stock
100 mg	￥4580	In stock
250 mg		Get quote

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生物&药学活性

Volasertib (BI 6727) is a potent, selective Polo-like kinase (PLK) inhibitor with IC50 of 0.87, 5 and 56 nM for PLK1, 2 and 3, respectively.
Volasertib (BI 6727) displays no inhibitory activity against a panel of >50 other kinases.
Volasertib (BI 6727) inhibits proliferation of multiple cell lines derived from various cancer tissues, including HCT116 (EC50=23 nM) and NCI-H460 (EC50=21 nM),BRO (EC50=11 nM), and hematopoietic cancer cell HL-60 (EC50=32 nM).
Volasertib (BI 6727) demonstrates marked antitumor activity in multiple cancer models, including a model of taxane-resistant colorectal cancer.

物理化学性质&存储条件

分子量	618.8126
分子式	C34H50N8O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Benzamide, N-[trans-4-[4-(cyclopropylmethyl)-1-piperazinyl]cyclohexyl]-4-[[(7R)-7-ethyl-5,6,7,8-tetrahydro-5-methyl-8-(1-methylethyl)-6-oxo-2-pteridinyl]amino]-3-methoxy-

参考文献

1. Rudolph D, et al. Clin Cancer Res. 2009 May 1;15(9):3094-102.

2. Grinshtein N, et al. Cancer Res. 2011 Feb 15;71(4):1385-95.

3. Schöffski P, et al. Eur J Cancer. 2012 Jan;48(2):179-86.

4. Sanhaji M, et al. Cell Cycle. 2012 Feb 1;11(3):543-53.

Volasertib (BI 6727, BI-6727, BI6727)

生物&药学活性

物理化学性质&存储条件

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Volasertib (BI 6727, BI-6727, BI6727)

生物&药学活性

物理化学性质&存储条件

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