HMN-214 |CAS:173529-46-9 Probechem Biochemicals

Chemical Structure : HMN-214

CAS No.: 173529-46-9

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HMN-214 (IVX-214;HMN214;TV-7101;IVX 214;;IVX214)

货号: PC-42860Not For Human Use, Lab Use Only.

HMN-214 (IVX 214, TV-7101) is a prodrug of HMN-176 for oral administration, HMN-176 is a stilbene derivative that interferes with the subcellular spatial location of PLK1, does not inhibit PLK directly.

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10 mg	￥980	In stock
25 mg	￥1480	In stock
50 mg	￥2380	In stock
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生物&药学活性

HMN-214 (IVX 214, TV-7101) is a prodrug of HMN-176 for oral administration, HMN-176 is a stilbene derivative that interferes with the subcellular spatial location of PLK1, does not inhibit PLK directly.
HMN-214 suppresses the expression of MDR1 mRNA in mouse xenograft model implanted with KB-A.1, an Adriamycin-resistant cell line.
HMN-176 inhibits the Y-box-dependent promoter activity of the MDR1 gene in a dose-dependent manner.

物理化学性质&存储条件

分子量	424.4696
分子式	C22H20N2O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Acetamide, N-[(4-methoxyphenyl)sulfonyl]-N-[2-[(1E)-2-(1-oxido-4-pyridinyl)ethenyl]phenyl]-

参考文献

1. Tanaka H, et al. Cancer Res. 2003 Oct 15;63(20):6942-7.

2. Takagi M, et al. Invest New Drugs. 2003 Nov;21(4):387-99.

3. Garland LL, et al. Clin Cancer Res. 2006 Sep 1;12(17):5182-9.

4. Christensen MD, et al. J Control Release. 2015 Apr 28;204:20-9.

HMN-214 (IVX-214;HMN214;TV-7101;IVX 214;;IVX214)

生物&药学活性

物理化学性质&存储条件

参考文献

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HMN-214 (IVX-214;HMN214;TV-7101;IVX 214;;IVX214)

生物&药学活性

物理化学性质&存储条件

参考文献

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