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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-Polo-like Kinase (PLK)-ON1231320
ON1231320

Chemical Structure : ON1231320

CAS No.: 1312471-39-8

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ON1231320 (ON 1231320)

货号: PC-73207Not For Human Use, Lab Use Only.

ON1231320 is a highly specific, ATP-mimetic polo-like kinase 2 (PLK2) inhibitor with IC50 of 0.31 uM.

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5 mg ￥980 In stock
10 mg ￥1580 In stock
25 mg ￥2680 In stock
50 mg ￥4580 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

ON1231320 is a highly specific, ATP-mimetic polo-like kinase 2 (PLK2) inhibitor with IC50 of 0.31 uM.
ON1231320 displays no activity against PLK1//3/4 (IC50>50 uM), high selectivity against a panel of 288 wild-type, 55 mutant and 12 special kinases.
ON1231320 affects cell cycle progression by blocking tumor cells in the G2/M phase however it does not affect normal human fibroblasts.
ON1231320 has anticancer effects in glioma cells.

物理化学性质&存储条件

分子量 467.45
分子式 C22H15F2N5O3S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-((1H-Indol-5-yl)amino)-6-((2,4-difluorophenyl)sulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one

参考文献

1. M V Ramana Reddy, et al. Bioorg Med Chem. 2016 Feb 15;24(4):521-44.

2. Shashidhar S. Jatiani, et al. Cancer Res (2011) 71 (8_Supplement): 643.

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