GSK461364 |CAS:929095-18-1 Probechem Biochemicals

Chemical Structure : GSK461364

CAS No.: 929095-18-1

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GSK461364 (GSK461364A, GSK-461364)

货号: PC-45884Not For Human Use, Lab Use Only.

GSK461364 is a potent, selective, and reversible ATP-competitive PLK1 inhibitor with Ki of 2.2 nM.

规格	价格	库存
5 mg	￥880	In stock
10 mg	￥1280	In stock
25 mg	￥2180	In stock
50 mg	￥3680	In stock
100 mg		Get quote

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生物&药学活性

GSK461364 is a potent, selective, and reversible ATP-competitive PLK1 inhibitor with Ki of 2.2 nM.
GSK461364 displays >390-fold greater selectivity for Plk1 than for Plk2 and Plk3 and 1,000-fold greater selectivity than for a panel of 48 other kinases.
GSK461364 shows antiproliferative activity against >120 tumor cell lines and potently inhibits the proliferation with IC50s of <100 nM.
GSK461364 shows clear antitumor activity in human tumor xenograft models.

物理化学性质&存储条件

分子量	543.6038
分子式	C27H28F3N5O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-Thiophenecarboxamide, 5-[6-[(4-methyl-1-piperazinyl)methyl]-1H-benzimidazol-1-yl]-3-[(1R)-1-[2-(trifluoromethyl)phenyl]ethoxy]-

参考文献

1. Olmos D, et al. Clin Cancer Res. 2011 May 15;17(10):3420-30.

2. Gilmartin AG, et al. Cancer Res. 2009 Sep 1;69(17):6969-77.

3. Degenhardt Y, et al. Mol Cancer Ther. 2010 Jul;9(7):2079-89.

GSK461364 (GSK461364A, GSK-461364)

生物&药学活性

物理化学性质&存储条件

参考文献

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GSK461364 (GSK461364A, GSK-461364)

生物&药学活性

物理化学性质&存储条件

参考文献

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