Poloppin |CAS:683808-78-8 Probechem Biochemicals

Chemical Structure : Poloppin

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Poloppin

货号: PC-61200Not For Human Use, Lab Use Only.

Poloppin is a cell-active, small molecule inhibitor of protein-protein interaction via the Polo-box domain (PBD) of the mitotic Polo-like kinase (PLK) with IC50 of 26.9 uM (PLK1) in FP assays.

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生物&药学活性

Poloppin is a cell-active, small molecule inhibitor of protein-protein interaction via the Polo-box domain (PBD) of the mitotic Polo-like kinase (PLK) with IC50 of 26.9 uM (PLK1) in FP assays.
Poloppin triggers dose-dependent mitotic arrest with non-congressed chromosomes in human cell lines, preferentially kills cells expressing mutant KRAS (SW48 G12D GI50=5.2 uM, SW48 Wt GI50=13.7 uM).
Poloppin sensitizes mutant KRAS-expressing cells to clinical inhibitors of c-MET.

物理化学性质&存储条件

分子量	438.244
分子式	C20H15BrF3NO2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(5-(4-bromophenyl)-1-(2-(trifluoromethyl)phenyl)-1H-pyrrol-2-yl)propanoic acid

参考文献

1. Narvaez AJ, et al. Cell Chem Biol. 2017 Aug 17;24(8):1017-1028.e7.

Poloppin

生物&药学活性

物理化学性质&存储条件

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Poloppin

生物&药学活性

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