Poloppin II |CAS: 2248068-54-2 Probechem Biochemicals

Chemical Structure : Poloppin II

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Poloppin II (Poloppin-II)

货号: PC-61201Not For Human Use, Lab Use Only.

Poloppin II is an orally active, Poloppin derivative inhibitor of protein-protein interaction via the PBD of the mitotic Polo-like kinase (PLK) with IC50 of 41 uM in FP assays, exhibits IC50 of 61 nM cellular assay for mitotic arrest.

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生物&药学活性

Poloppin II is an orally active, Poloppin derivative inhibitor of protein-protein interaction via the PBD of the mitotic Polo-like kinase (PLK) with IC50 of 41 uM in FP assays, exhibits IC50 of 61 nM cellular assay for mitotic arrest。
Poloppin II is also active against PLK2 PDB with an IC50 of 105 uM in FP assay, engages PLK1 and PLK4, sensitizes cells expressing mutant KRAS by approximately 5-fold。
Poloppin II demonstrates effectivity gainst KRAS-expressing cancer xenografts.

物理化学性质&存储条件

分子量	511.973
分子式	C28H25ClF3N3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(5-(4-chlorophenyl)-1-(2-(trifluoromethyl)phenyl)-1H-pyrrol-2-yl)-N-(2-(dimethylamino)ethyl)benzamide

参考文献

1. Narvaez AJ, et al. Cell Chem Biol. 2017 Aug 17;24(8):1017-1028.e7.

Poloppin II (Poloppin-II)

生物&药学活性

物理化学性质&存储条件

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Poloppin II (Poloppin-II)

生物&药学活性

物理化学性质&存储条件

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