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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-Polo-like Kinase (PLK)-Cyclapolin 1
Cyclapolin 1

Chemical Structure : Cyclapolin 1

CAS No.: 736157-02-1

Cyclapolin 1

货号: PC-62159Not For Human Use, Lab Use Only.

Cyclapolin 1 is a potent and selective PLK1 inhibitor that promotes loss of centrosome integrity and microtubule nucleating ability apparently through increased accessibility of protein phosphatases.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    Cyclapolin 1 is a potent and selective PLK1 inhibitor that promotes loss of centrosome integrity and microtubule nucleating ability apparently through increased accessibility of protein phosphatases.
    Cyclapolin 1 treatment leads to collapsed spindles in living cells, in contrast to the metaphase-arrested bipolar spindles observed after RNAi.

    物理化学性质&存储条件

    分子量 339.263
    分子式 C9H4F3N3O4S2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    2-carbamoyl-7-nitro-5-((trifluoromethyl)thio)benzo[d]thiazole 3-oxide

    参考文献

    1. McInnes C, et al. Nat Chem Biol. 2006 Nov;2(11):608-17.

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