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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-Polo-like Kinase (PLK)-Poloxin
Poloxin

Chemical Structure : Poloxin

CAS No.: 321688-88-4

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Poloxin

货号: PC-62393Not For Human Use, Lab Use Only.

Poloxin is the first reported PLK1 PBD inhibitor with IC50 of 6.4 uM, shows less potent inhibition for Plk2 PBD and Plk3 PBD.

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50 mg ￥1380 In stock
100 mg ￥2180 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Poloxin is the first reported PLK1 PBD inhibitor with IC50 of 6.4 uM, shows less potent inhibition for Plk2 PBD and Plk3 PBD.
Poloxin inhibits the function of the Plk1 PBD in vitro, and cause Plk1 mislocalization, chromosome congression defects, mitotic arrest, and apoptosis in HeLa cells.
Poloxin activates the spindle assembly checkpoint and inhibits tumor growth in xenograft mouse models.

物理化学性质&存储条件

分子量 297.354
分子式 C18H19NO3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-Methyl-5-(1-methylethyl)-1-[O-(2-methylbenzoyl)oxime]-2,5-Cyclohexadiene-1,4-dione

参考文献

1. Reindl W, et al. Chem Biol. 2008 May;15(5):459-66.

2. Scharow A, et al. ACS Chem Biol. 2015 Nov 20;10(11):2570-9.

3. Yuan J, et al. Am J Pathol. 2011 Oct;179(4):2091-9.

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