| Cat. No. |
Product Name |
Information |
| PC-20734 |
AG-1031
PC4 inhibitor
|
AG-1031 (AG1031) is a specific small molecule inhibitor of the double-stranded DNA binding activity of positive coactivator 4 (PC4) with IC50 of 2.5 uM, more effectively than its single-stranded DNA binding activity (IC50=15 uM). |
| PC-20217 |
NACK inhibitor UM-74
NACK inhibitor
|
UM-74 is a potent and specifc inhibitor of NACK (Notch activation complex kinase), directly blocks NACK recruitment to the Notch ternary complex (NTC). |
| PC-20216 |
Z271-0326
NACK inhibitor
|
Z271-0326 is a first-in-class, potent and specifc inhibitor of NACK (Notch activation complex kinase) with SPR KD value of 0.89 uM, directly blocks NACK recruitment to the Notch ternary complex (NTC). |
| PC-73042 |
RBPJ Inhibitor 1
RBPJ inhibitor
|
RBPJ Inhibitor 1 (RIN1) is a small molecule inhibitor that disrupts the interaction between NOTCH and RBPJ, inhibits RBPJ-VP16-dependent Hes1-Luciferase in AD-293 cells with IC50 of 0.2 uM. |
| PC-72454 |
NADI-351
Notch1 inhibitor
|
NADI-351 is a specific small-molecule inhibitor of Notch1 transcriptional complexes with IC50 of 8.8 uM in cellualr reporter assays. |
| PC-38269 |
CAD204520
SERCA inhibitor
|
CAD204520 (CAD 204520) is a potent, specific, orally available inhibitor of SERCA (Sarco/Endoplasmic Reticulum Calcium ATPase) with IC50 of 0.34 uM. |
| PC-38257 |
CB-103
Notch inhibitor
|
CB-103 (CB103) is an orally active small-molecule inhibitor of the Notch transcription activation complex, inhibits both ligand-dependent and ligand-independent Notch activation in cell-based assays (IC50=0.9-3.9 uM). |
| PC-38195 |
ASR490
Notch1 inhibitor
|
ASR490 (ASR 490) is a small molecule that binds to NRR of Notch1, specifically inhibits Notch1-mediated survival of colorectal cancer cells (IC50=0.6-1.2 uM). |
| PC-35995 |
NVS-ZP7-4
SLC39A7 inhibitor, Notch inhibitor
|
NVS-ZP7-4 is specific small molecule inhibitor of SLC39A7 (ZIP7), inhibits Notch signaling with IC50 of 0.13 uM in HES-Luc reporter gene assays, selectively induces apoptosis and ER stress. |
| PC-63562 |
BMS-871
Notch inhibitor
|
BMS-871 (BMS871) is a potent, orally active pan-Notch inhibitor with IC50 of 4/1/4/3 nM for Notch1/2/3/4, respectively. |
| PC-63504 |
Yhhu-3792
Notch activator
|
Yhhu-3792 is a novel small molecule that enhances the self-renewal capability of neural stem cells (NSCs) in vitro and in vivo via activating the Notch signaling pathway. |
| PC-43039 |
LY3039478
Notch inhibitor
|
LY3039478 (Crenigacestat) is an exquisitely potent inhibitor of Notch-1 intracellular domain (N1ICD) cleavage with IC50 of 1 nM, also potently inhibits mutant Notch receptor activity. |
